The Immunostimulant Effect of Raspberry (Rubus idaeus) Fruit Ethanol Extract Through Carbon Clearance Index and Organ Index
EFEK IMUNOSTIMULAN EKSTRAK ETANOL BUAH RASPBERRY (Rubus idaeus) MELALUI INDEKS BERSIHAN KARBON DAN INDEKS ORGAN
DOI:
https://doi.org/10.29313/jiff.v8i1.4820Abstract
Raspberry fruit ethanol extract is known to have strong antioxidant activity and which is related with immunostimulant activity. This study aims to determine the immunostimulant activity of ethanol extract of raspberry fruit.Raspberry fruit is macerated with 70% ethanol and concentrated using a rotary evaporator, then the phagocytosis index, spleen and liver index in mice are determined using the carbon clearence method.Based on the results obtained, it is known that all doses have immunostimulant activity because there are significant differences (p <0.05) between all doses against the negative control group with a dose of 400mg / kgBB having the highest value among the test groups and having moderate immunostimulant activity.
References
Abebe, D., Karim, A., Bitew, H., & Periasamy, G. (2022). In-vivo evaluation of immunomodulatory activity of crude extract and solvent fractions of Cyphostemma adenocaule (Steud. ex A.Rich). Heliyon, 8(12). https://doi.org/10.1016/j.heliyon.2022.e12377
Aldi, Y., Ogiana, N., & Handayani, D. (2014). Uji Imunomodulator Beberapa Subfraksi Ekstrak Etil Asetat Meniran (Phyllanthus niruri [L]) Pada Mencit Putih Jantan dengan Metoda Carbon Clearance. In Jurnal B-Dent (Vol. 1, Issue 1).
Almajid, G. A. A., Rusli, R., & Priastomo, M. (2021). Pengaruh Pelarut, Suhu, dan pH Terhadap Pigmen Antosianin dari Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus). Proceeding of Mulawarman Pharmaceuticals Conferences, 14, 179–185. https://doi.org/10.25026/mpc.v14i1.557
Baratawidjaja, K. G. (2014). Imunologi Dasar Edisi Ke 11. Badan Penerbit FK UI.
Chen, L., Xin, X., Zhang, H., & Yuan, Q. (2013). Phytochemical properties and antioxidant capacities of commercial raspberry varieties. Journal of Functional Foods, 5(1), 508–515. https://doi.org/https://doi.org/10.1016/j.jff.2012.10.009
Depkes RI. (2017). Farmakope Herbal Indonesia Edisi II (II). Depkes RI.
Diaconeasa, Z., Ranga, F., Rugină, D., Leopold, L., Pop, O. L., Vodnar, D., Cuibus, L., & Socaciu, C. (2015). Phenolic Content and Their Antioxidant Activity in Various Berries Cultivated in Romania. Vol 72, No 1 (2015) BULLETIN OF UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE CLUJ-NAPOCA. FOOD SCIENCE AND TECHNOLOGY, 72. https://doi.org/10.15835/buasvmcn-fst:11127
Fadillah Maryam. (2020). Pengukuran Parameter Spesifik Dan Non Spesifik Ekstrak Etanol Daun Matoa (Pometia pinnata J.R & G.Forst). Jurnal Mandala Pharmacon Indonesia, 6(1).
Harborne, J. B. (1987). Metode Fitokimia. ITB Press.
Isdadiyanto, S., & Tana, S. (2019). Struktur Histologi Hepar Tikus Wistar (Rattus norvegicus) Jantan setelah Pemberian Teh Kombucha Konsentrasi 75% dengan Waktu Fermentasi yang Berbeda. Bioma, 21(2), 2598–2370.
Kemenkes RI. (2018). Riset Kesehatan Dasar (RISKESDAS). Balitbang Kemenkes RI.
Kolesarova, A., Baldovska, S., Kohut, L., & Sirotkin, A. V. (2022). Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction. In Pharmaceuticals (Vol. 15, Issue 2). MDPI. https://doi.org/10.3390/ph15020239
Kumolosasi, E., Ibrahim, S. N. A., Shukri, S. M. A., & Ahmad, W. (2018). Immunostimulant activity of standardised extracts of mangifera indica leaf and curcuma domestica rhizome in mice. Tropical Journal of Pharmaceutical Research, 17(1), 77–84. https://doi.org/10.4314/tjpr.v17i1.12
Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M. T., Wang, S., Liu, H., & Yin, Y. (2016). Quercetin, inflammation and immunity. In Nutrients (Vol. 8, Issue 3). MDPI AG. https://doi.org/10.3390/nu8030167
Marshall, J. S., Warrington, R., Watson, W., & Kim, H. L. (2018). An introduction to immunology and immunopathology. In Allergy, Asthma and Clinical Immunology (Vol. 14). BioMed Central Ltd. https://doi.org/10.1186/s13223-018-0278-1
Siska, Diene Roufiani, & Ema Dewanti. (2020). Anti-allergic Activity of 70% Ethanol Extract of Strawberries in Ovalbumin Induced Male Mice. Jurnal Jamu Indonesia, 5(3), 92–97. https://doi.org/10.29244/jji.v5i3.167
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