EVALUATION OF THE USE OF ANTIHYPERTENSIVE DRUGS IN INPATIENT PREECLAMPSIA PATIENTS IN THE LEMBANG REGIONAL HOSPITAL
EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN PREEKLAMPSIA RAWAT INAP DI RUMAH SAKIT DAERAH LEMBANG
DOI:
https://doi.org/10.29313/jiff.v7i2.3676Keywords:
pregnancy, antihypertensive, preeclampsiaAbstract
Preeclampsia is one of the complications that often occurs in pregnant women. The prevalence of preeclampsia in Indonesia occurs in three point three percent of pregnant women and often leads to death. The mortality rate due to preeclampsia is the second highest cause after hemorrhage. However, with proper management, deaths due to preeclampsia can be prevented. This study aims to evaluate the accuracy of the use of antihypertensive drugs in pregnant women with preeclampsia at one hospital in the Lembang area. The research method is descriptive observational and retrospectively, using medical record data from patients with the primary diagnosis of preeclampsia. Samples were taken using consecutive sampling method that met the inclusion criteria. Parameters observed were appropriate indication, dosage, drug, and frequency of administration. The research indiacted that the administration of antihypertensive drugs in preeclampsia womens at one hospital in the Lembang area has met the criteria for appropriate indication, drug, dosage, and frequency of drug administration.
References
AHFS. (2020). AHFS Drugs Information, American Society of Health- System Pharmacists.
DiPiro, J. D., Schwinghammer, T., Ellingrod, V., & DiPiro, C. (2023). Pharmacotherapy DiPiros Handbook. Mc.Graw HIll.
Dwi, D., Utami, E. D., & Kurnia, N. (2018). Evaluasi Penggunaan Obat Antihipertensi pada Pasien Pre-Eklampsia Rawat Inap di RSUD Prof . Dr . Margono Soekarjo Purwokerto Drug Use Evaluation of Antihypertensive in Pre-Eclampsia In-Patients in Dr . Margono Soekarjo General Hospital Purwokerto. 6(1), 29–39. https://doi.org/10.5281/zenodo.3707186
English, F. A., Kenny, L. C., Mccarthy, F. P., English, F. A., Kenny, L. C., Mccarthy, F. P., & Mccarthy, F. P. (2015). Risk factors and effective management of preeclampsia Risk factors and effective management of preeclampsia. https://doi.org/10.2147/IBPC.S50641
Hong, B., Ding, X., Iia, H., & Zhang, J. (2018). Combination treatment of captopril and prazosin to treat patients with gestational hypertension. Experimental and Therapeutic Medicine, 16(4), 3694–3702. https://doi.org/10.3892/etm.2018.6604
Kaye, A. B., Bhakta, A., Moseley, A. D., Rao, A. K., Arif, S., Lichtenstein, S. J., Aggarwal, N. T., Volgman, A. S., & Sanghani, R. M. (2019). Review of Cardiovascular Drugs in Pregnancy. Journal of Women’s Health, 28(5), 686–697. https://doi.org/10.1089/jwh.2018.7145
Madania, Abdulkadir, W. S., Djuwarno, E. N., Mu, A., & Sherina. (2024). Studi Penatalaksanaan dan Ketepatan Pengobatan Antihipertensi pada Wanita Hamil di RSUD Toto Kabila. Journal Syifa Sciences & Clinical Research, 6(May 2023), 34–45.
Melanie M. Maykin, Elizabeth Mercer, Kevin M. Saiki, Bliss Kaneshiro, Corrie B. Miller, Pai-Jong Stacy Tsai, Furosemide to lower antenatal severe hypertension: a randomized placebo-controlled trial, American Journal of Obstetrics & Gynecology MFM, 6(4).
Nirupama, R., Divyashree, S., Janhavi, P., Muthukumar, S. P., & Ravindra, P. V. (2021). Preeclampsia: Pathophysiology and Management. Journal of Gynecology Obstetrics and Human Reproduction, 50(2). https://doi.org/10.1016/j.jogoh.2020.101975
POGI. (2016). Pedoman Nasional Pelayanan Kedokteran: Diagnosis dan Tatalaksana Preeklampsia.
Queensland Clinical Guidelines (2021). Hypertension and pregnancy. Guideline No.MN21.13-V9-R26. Queensland Health. Available from: http://www.health.qld.gov.au/qcg
Rana, S., Lemoine, E., Granger, J., & Karumanchi, S. A. (2019). Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation Research, 124(7), 1094–1112. https://doi.org/10.1161/CIRCRESAHA.118.313276
Songthamwat, S., Na Nan, C., & Songthamwat, M. (2018). Effectiveness of nifedipine in threatened preterm labor: A randomized trial. International Journal of Women’s Health, 10, 317–323. https://doi.org/10.2147/IJWH.S159062
Temming, L. A., Cahill, A. G., & Riley, L. E. (2016). Clinical management of medications in pregnancy and lactation. American Journal of Obstetrics and Gynecology, 214(6), 698–702. https://doi.org/10.1016/j.ajog.2016.01.187
Thakur, V., Thakur, A., & Saroshe, S. (2016). Comparison of effect of nifedipine, labetalol and methyldopa in treatment of hypertension in pregnancy in a tertiary care government hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, December 2015, 17–22. https://doi.org/10.18203/2320-1770.ijrcog20151495
Van de Vusse, D., Mian, P., Schoenmakers, S., Flint, R. B., Visser, W., Allegaert, K., & Versmissen, J. (2022). Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. European Journal of Clinical Pharmacology, 78(11), 1763–1776. https://doi.org/10.1007/s00228-022-03382-3
Vigil-De Gracia, P., Dominguez, L., & Solis, A. (2014). Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial. The Journal of Maternal-Fetal & Neonatal Medicine, 27(13), 1291–1294. https://doi.org/10.3109/14767058.2013.852180
Yin, J., Mei, Z., Shi, S. Du, P., Qin, S. (2022). Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. Arch Gynecol Obstet, 306(6), 1891–1900. https://doi.org/10.1007/s00404-022-06504-5
English, F. A., Kenny, L. C., Mccarthy, F. P., English, F. A., Kenny, L. C., Mccarthy, F. P., & Mccarthy, F. P. (2015). Risk factors and effective management of preeclampsia Risk factors and effective management of preeclampsia. https://doi.org/10.2147/IBPC.S50641
Hong, B., Ding, X., Iia, H., & Zhang, J. (2018). Combination treatment of captopril and prazosin to treat patients with gestational hypertension. Experimental and Therapeutic Medicine, 16(4), 3694–3702. https://doi.org/10.3892/etm.2018.6604
Kaye, A. B., Bhakta, A., Moseley, A. D., Rao, A. K., Arif, S., Lichtenstein, S. J., Aggarwal, N. T., Volgman, A. S., & Sanghani, R. M. (2019). Review of Cardiovascular Drugs in Pregnancy. Journal of Women’s Health, 28(5), 686–697. https://doi.org/10.1089/jwh.2018.7145
Madania, Abdulkadir, W. S., Djuwarno, E. N., Mu, A., & Sherina. (2024). Studi Penatalaksanaan dan Ketepatan Pengobatan Antihipertensi pada Wanita Hamil di RSUD Toto Kabila. Journal Syifa Sciences & Clinical Research, 6(May 2023), 34–45.
Melanie M. Maykin, Elizabeth Mercer, Kevin M. Saiki, Bliss Kaneshiro, Corrie B. Miller, Pai-Jong Stacy Tsai, Furosemide to lower antenatal severe hypertension: a randomized placebo-controlled trial, American Journal of Obstetrics & Gynecology MFM, 6(4).
Nirupama, R., Divyashree, S., Janhavi, P., Muthukumar, S. P., & Ravindra, P. V. (2021). Preeclampsia: Pathophysiology and Management. Journal of Gynecology Obstetrics and Human Reproduction, 50(2). https://doi.org/10.1016/j.jogoh.2020.101975
POGI. (2016). Pedoman Nasional Pelayanan Kedokteran: Diagnosis dan Tatalaksana Preeklampsia.
Queensland Clinical Guidelines (2021). Hypertension and pregnancy. Guideline No.MN21.13-V9-R26. Queensland Health. Available from: http://www.health.qld.gov.au/qcg
Rana, S., Lemoine, E., Granger, J., & Karumanchi, S. A. (2019). Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation Research, 124(7), 1094–1112. https://doi.org/10.1161/CIRCRESAHA.118.313276
Songthamwat, S., Na Nan, C., & Songthamwat, M. (2018). Effectiveness of nifedipine in threatened preterm labor: A randomized trial. International Journal of Women’s Health, 10, 317–323. https://doi.org/10.2147/IJWH.S159062
Temming, L. A., Cahill, A. G., & Riley, L. E. (2016). Clinical management of medications in pregnancy and lactation. American Journal of Obstetrics and Gynecology, 214(6), 698–702. https://doi.org/10.1016/j.ajog.2016.01.187
Thakur, V., Thakur, A., & Saroshe, S. (2016). Comparison of effect of nifedipine, labetalol and methyldopa in treatment of hypertension in pregnancy in a tertiary care government hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, December 2015, 17–22. https://doi.org/10.18203/2320-1770.ijrcog20151495
Van de Vusse, D., Mian, P., Schoenmakers, S., Flint, R. B., Visser, W., Allegaert, K., & Versmissen, J. (2022). Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. European Journal of Clinical Pharmacology, 78(11), 1763–1776. https://doi.org/10.1007/s00228-022-03382-3
Vigil-De Gracia, P., Dominguez, L., & Solis, A. (2014). Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial. The Journal of Maternal-Fetal & Neonatal Medicine, 27(13), 1291–1294. https://doi.org/10.3109/14767058.2013.852180
Yin, J., Mei, Z., Shi, S. Du, P., Qin, S. (2022). Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis. Arch Gynecol Obstet, 306(6), 1891–1900. https://doi.org/10.1007/s00404-022-06504-5
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Isti Elvina Azzahra, Ratu Choesrina, Umi Yuniarni
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
