AKTIVITAS ANTIDEPRESAN MINYAK ATSIRI BIJI PALA (Myristica fragrans) TERHADAP MENCIT JANTAN SWISS WEBSTER (Mus musculus): AKTIVITAS ANTIDEPRESAN MINYAK ATSIRI BIJI PALA (Myristica fragrans) TERHADAP MENCIT JANTAN SWISS WEBSTER (Mus musculus)

Riadatun Nabila; Inaratul Rizkhy Hanifah; Dian Marlina; Hery Muhamad Ansory

doi:10.29313/jiff.v7i2.3108

Authors

Riadatun Nabila S1 Farmasi, Fakultas Farmasi Universitas Setia Budi
Inaratul Rizkhy Hanifah Fakultas Farmasi Universitas Setia Budi
Dian Marlina Fakultas Farmasi Universitas Setia Budi
Hery Muhamad Ansory fakultas Farmasi, Universitas Setia Budi

DOI:

https://doi.org/10.29313/jiff.v7i2.3108

Keywords:

antidepressant, nutmeg seed, essential oil

Abstract

Nutmeg seed essential oil has been reported to have an antidepressant effect, but there is not much scientific evidence regarding an optimal dose of nutmeg seed essential oil as an antidepressant. The goal of this research is to gain an optimal dose of nutmeg seed essential oil towards increasing exploratory activity and decreasing the duration of immobility in mice. The sample of this research is nutmeg essential oil and also using a Forced Swimming test and Open Field test to exploratory activity and immobility. This research using amitriptillin for positive control, dose 5 mg/KgBW mice , dose 10 mg/KgBW mice and dose 20 mg/KgBW mice. The result showed the optimum dose is 5 mg/KgBW mice which able to decrease the immobility and increase the exploratory activity on mice. The decreasing immobility time and exploratory activity are provided by statistic analysis paired t-test with sig. p(<0,05).

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