Jurnal Ilmiah Farmasi Farmasyifa

TREATMENT PERCEPTIONS ON SATISFACTION THERAPY WITH DIABETES MELLITUS TYPE II PATIENTS

2024-01-10T15:27:16+08:00

One of the multifactorial diseases with a high prevalence in Palu City in 2021 is diabetes mellitus. There are 26,204 people suffering from type II diabetes mellitus. This study aims to determine the relationship between treatment perception and satisfaction of patients with type II diabetes mellitus at one of the regional general hospitals in Palu City. The research method used was observational with cross-sectional method, as many as 100 respondents were used in this study with random sampling technique, data collection using general Beliefs about Medication2 Questionnaire (BMQ) instrument and Diabetic Medication Satisfaction Tool (DMSAT). The results showed that the treatment perceptions of the respondents were in category of negative perception (42%) and positive perception (58%), for therapy satisfaction the results were in category of very satisfied (6%), satisfied (86%) and moderately satisfied (8%). From the results of the chi-square test, the p-value is 0.042, which means that there is a relationship between treatment perceptions and respondents' therapy satisfaction. Therefore, it can be concluded that the factor treatment perception is able to increase therapy satisfaction in type II diabetes mellitus patients. This study is expected to provide input to improve pharmaceutical services in the provision of therapy to patients with chronic diseases.

COST ANALYSIS OF SCHIZOPHRENIA PATIENTS USING ANTIPSYCHOTIC THERAPY AT MADANI HOSPITAL IN CENTRAL SULAWESI

2023-12-27T13:04:43+08:00

Treatment of schizophrenia cannot be separated from the burden of costs that must be borne by the patient. This study aims to determine the average direct medical costs with length of stay 14 days and >14 days from schizophrenia not classified (YTT), schizophrenia not detail and paranoid schizophrenia, knowing the average cost of antipsychotic monotherapy, combination 2, combination 3, combination 4 and combination 5 drugs from schizophrenia patients and knowing the average cost of direct medical components for schizophrenia patients at Madani Hospital, Central Sulawesi in 2019. This study is a type of non-experimental research that is analyzed descriptively and data collection is carrised out retrospectively from medical record data of schizophrenia patients in 2019. The results obtained from the cost analysis are the direct medical average costs of various types of schizophrenia, namely schizophrenia that is not classified (YTT) length of stay 14 days on average Rp 3,192,799±1,750,585 and length of stay >14 days Rp 6,107,006±2,465,655; unspecified schizophrenia length of stay 14 days an average of Rp 2,743,787±792,356 and length of stay >14 days an average of Rp 6,207,815±1,994,428 and paranoid schizophrenia length of stay 14 days an average of Rp 3,145,466± 3,145,466 and length of stay >14 days on average Rp 9,547,824±0; the average cost of antipsychotic treatment for schizophrenic patients, namely monotherapy treatment an average of IDR 36,266±8,457, a combination of 2 drugs an average of IDR 74,428, a combination of 3 drugs an average of IDR 44,279±32,746, a combination of 4 drugs an average of IDR 169,755±133,268, and a combination of 5 drugs an average of IDR 297,030 ± 0 and the average direct medical component cost that is most often incurred by schizophrenic patients is the cost of medical procedures with an average of IDR 1,468,907, or 33%.

ANALYSIS OF Pb (II) METAL CONTENT IN LIPSTICK SOLD ONLINE IN SAMARINDA CITY USING UV-VISIBLE SPECTROPHOTOMETRY

2023-12-27T20:18:09+08:00

Lipstick is a cosmetic preparation that serves to provide color to thelips. Lead (Pb) is a heavy metal that is accumulative and toxic. Lead has the property of beingsoluble in oil so that it is easily absorbed through the membranes or layers of the skin if the metal lead (Pb) is mixed intentionally in the lip color. intentionally incosmetic products and directly in contact with human skin. Objectiveof this study is to analyze the lead (Pb) content and determine the level of lead (Pb) in lipstick. lead (Pb) in lipsticks sold online in Samarinda City.in Samarinda City. Using UV-Visible spectrophotometric method. The results of the research obtained from 15 lipstick samples samples analyzed showed there were 6 lipstick samples, namely sample A7 (207 mg/kg), B1 (91.65 mg / kg), B2 (40.8 mg / kg), B3 (103.95 mg / kg), B4 (113.55 mg / kg), B5 (119.5 mg/kg) which have Lead (Pb) levels exceeding the BPOM requirements, namely ≤ 20 mg/kg. Conclusion of the research. The conclusion of this study is that there are still many lipsticks that do not meet health requirements and can be harmful to consumer health.

DRUG RELATED PROBLEMS IN THERAPY FOR PATIENTS WITH CONGESTIVE HEART FAILURE FOR THE PERIOD JULY DECEMBER 2020 AT RSUP H. ADAM MALIK MEDAN

2023-12-27T17:15:09+08:00

Congestive Heart Failure (CHF) is a condition where the heart fails to pump blood to meet the needs of body cells for adequate nutrients and oxygen. Pharmacological therapy performed on therapeutic treatment of patients with CHF can allow the occurrence of Drug Related Problems (DRPs). The identification of DRPs using the Strand Classification includes several criteria, namely indications without drugs, drugs without indications, wrong drugs, insufficient drug doses, excessive drug doses, adverse drug reactions, and drug interactions. This study aims to determine the incidence of DRPs in the therapy of hospitalized patients with congestive heart failure at H. Adam Malik Medan Hospital. This study uses the Retrospective method by collecting data on inpatients with CHD at H. Adam Malik Medan Hospital starting from July-December 2020 in patient medical record data. The data was analyzed using IBM SPSS Statistics. The results of the identification of DRPs in the therapeutic management of patients with the Main Diagnosis of CHD without complications and comorbidities in the hospitalization installation of H. Adam Malik Medan Hospital showed that out of 10 patients, there were 9 patients (90%) who experienced DRPs and 1 patient (10%) who did not experience DRPs. Consisting of indications without drugs 2 cases (11.8%), drug interactions 15 cases (88.2%), while drugs without indications, inappropriate drugs, less drug dose, more drug dose, and adverse drug reactions were not found (0%). It can be concluded that there is an incidence of DRPs in the therapy of Congestive Heart Failure patients at the H. Adam Malik Medan Central General Hospital for the period July - December 2020.

Keywords: Congestive Heart Failure, Drug Related Problems, H. Adam Malik Hospital Medan

TOTAL PHENOLIC CONTENT, FLAVONOIDS, AND ANTIOXIDANT ACTIVITY OF JALANTIR LEAVES (Coryza sumatrensis)

2024-01-18T14:27:13+08:00

Antioxidant plays an important role in the body's defense against various diseases, because antioxidant compounds were able to prevent the bad effects caused by free radicals. Phenolic compounds and flavonoids are known as natural antioxidant o from plants. Jalantir (Coryza sumatrensis) is known contain phenolic and flavonoid. The aim of this study was to determine total phenolic content, flavonoid content and antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The results showed that jalantir extract had a total phenolic content of 38.27 mg GAE/g and flavonoid content of 56.60 mg QE/g. Meanwhile, for the antioxidant activity, value of IC50 for extract, water fraction, ethyl acetate, and n-hexane were 9.76; 45.91; 60.75; and 74.31 ppm respectively. Jalantir extract was the strongest antioxidant category compared to other fractions.
Keywords: phenolics, flavonoids, antioxidant, jalantir

ANTIBACTERIAL ACTIVITY DETERMINATION OF SOURSOP PEEL EXTRACT (ANONNA MURICATA Linn) AGAINST PROPIONICACTERIUM ACNE

2024-01-15T17:12:23+08:00

The use of antibiotics for treatment, including acne treatment, has the potential to cause resistance. Therefore, acne treatment can be done using medicinal plants, in this case is soursop skin which considered as waste. This study aims to determine the antibacterial activity of soursop peel extract against the acne-causing bacteria Propionibacterium acne. Soursop peel extract was made using the Ultrasonic Assisted Extraction (UAE) method at a frequency of 50 Hz for 45 minutes. Antibacterial activity testing was carried out using the agar diffusion method using wells, at concentrations of 0.25%, 0.5%, 1%, 2%, 4% and 8%. Meanwhile, the determination of antibacterial activity was carried out using the turbidimetric method using Uv-Vis spectrophotometry. From the extraction process, the extract yield was 21.26%. Antibacterial activity testing showed that the MIC value of the test extract against P. acne bacteria was 1% and was bacteriostatic.

BILIRUBIN LEVEL, SGOT, AND SGPT OF RATS ON ACUTE TOXICITY OF BUTTERFLY PEA ETHANOL EXTRACT (Clitoria Ternatea L.)

2024-01-25T11:49:41+08:00

Butterfly pea flowers have medicinal properties as antioxidants, antidiabetic agents, hepatoprotectives, anti-obesity compounds, anti-inflammatory agents, and anticancer substances. To ensure the safety of drugs, toxicity testing is necessary. Acute toxicity testing is a method to assess the impact of toxicity on specific organs, with the liver being the most frequently studied organ. Acute toxicity parameters in the liver can be observed by measuring bilirubin levels, SGOT, and SGPT. The objectives of this research are to identify signs of acute toxicity in test animals after administering ethanol extract of butterfly pea flowers, determine the LD50 value of the ethanol extract in acute toxicity testing, and assess the influence of the ethanol extract of butterfly pea flowers on bilirubin levels in test animals. Ethanol is extracted from butterfly pea flowers using the maceration process, and a fixed-dose approach is employed to conduct the Fixed Dose Method. The research results reveal that a dose of 2000 mg/kgBW per kilogram of body weight of butterfly pea flower extract does not induce acute toxicity. Furthermore, the LD50 value for the dose of 2000mg/kgBW is classified as moderately toxic. Additionally, there is a significant impact on bilirubin levels with a significance value (2-tailed) of <0.05, which is 0.003, whereas SGOT and SGPT levels do not exhibit a significant influence with values >0.05, specifically SGOT at 0.759 and SGPT at 0.324.

OPTIMIZATION OF LOTION FROM CARROT AND LIME PEEL EXTRACT

2024-01-05T13:32:38+08:00

Excessive sun exposure can cause sunburn, premature aging and skin cancer. Carrot and lime peel are plants that have natural sun protection activity in the presence of β-carotene and flavonoids. This study aims to determine the most optimum lotion formulation from carrot extract and lime peel based on the simplex lattice design method, namely, various differences in the amount of ingredient composition where the total amount of ingredients is made the same. Lotion from carrot extract and lime peel was made with a ratio of FI (12.5% lime peel : 0% carrot), FII (6.25% lime peel : 6.25% carrot), FIII (0% lime peel : 12.5% carrot) with the total amount of ingredients is the same. Carrot extract lotion and lime peel (FI, FII, FIII) have a pH that complies with the requirements, namely, 7.26 – 7.43 with antioxidant activity ranging from 344.39 ppm – 525.68 ppm. FI lotion (6.66) has a greater SPF lotion value compared to FII (3.46) and FIII (1.31). The most optimum formulation of carrot extract lotion and lime peel based on normality calculations (pH, antioxidants and SPF values), namely, FI (12.5% lime peel: 0% carrot).

IN-SILICO ANALYSIS OF TRANSMEMBRANE PROTEIN L1 HPV TYPE 52 FROM INDONESIAN ISOLATE

2023-12-10T10:54:49+08:00

The transmembrane region is the region of a protein that is inserted into the cell and has a hydrophobic tendency. One of these regions can be found in the L1 protein, which is a protein that makes up the human papillomavirus (HPV) icosahedral capsid. HPV (Human Papillomavirus) is a virus causing cervical cancer both nationally and globally. Cervical cancer is the third main cause of cancer in women globally and the first main cause in Indonesia. One of the most common types of HPV causing cervical cancer in Indonesia is HPV type 52, with the highest prevalence of around 23.2%. Development of a VLP-based vaccine using L1 HPV type 52 isolated from Indonesia is needed. VLP was the result of L1 protein assembly. However, L1 protein has a transmembrane region that is mostly hydrophobic and will usually form an aggregate. it will cause the targeted protein to settle in the water. Therefore, in this study, an analysis of the transmembrane region of the L1 HPV type 52 protein was carried out which had undergone cleavage of several bases at the N-terminal and C-terminal. The results showed that the recombinant L1 HPV type 52 protein, which is a truncated segment, did not have a transmembrane region when compared to the native L1 HPV type 52 protein.

Keyword: Hydrophobic, L1 HPV 52, and Transmembrane region