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A Recombinant DNA Technique in The Genetic Engineering of Insulin from Bacteria

Authors

  • Khaidir Yusuf rahman Universitas islam bandung
  • Sanely
  • Defa Pratama
  • Ziske Maritska

DOI:

https://doi.org/10.29313/jrk.v3i2.2626

Keywords:

Recombinant DNA, Genetic Enginerring, Insulin from bacteria

Abstract

Abstract. Human Growth and human insulin were the first proteins to be produced on an industrial scale. Methods: The research method used in this study was a clinical literature review on recombinant DNA techniques from insulin in bacteria from the review literature taken from Pubmed and SCopus, for further search and analysis with other existing research. Recombinant DNA technology comprises altering genetic material outside an organism to obtain enhanced and desired characteristics in living organisms or as their products. Two biosynthetic insulin analogs have sufficiently long duration of action for use as once-daily basal insulins. Some biosimilars have been developed to human insulins as produced by Lilly and NovoNordisk, but their use is more restricted given the problems encountered by the use of human insulin, see Dolinar et al for a recent review of the field. Several companies have developed or are developing depot preparations that can be administered one a week instead of once a day. Recombinant DNA technology is an important development in science that has made the human life much easier. The clinical effect of Growth hormone therapy in children can be best measured on an annual basis and compared with predicted adult height whereas failure to lower blood sugar can be seen immediately in insulin or insulin analogue therapy.

Abstrak. Pertumbuhan Manusia dan insulin manusia adalah protein pertama yang diproduksi dalam skala industri. Metode penelitian yang digunakan dalam penelitian ini adalah tinjauan literatur klinis mengenai teknik DNA rekombinan dari insulin pada bakteri dari tinjauan literatur yang diambil dari Pubmed dan SCopus, untuk selanjutnya dicari dan dianalisis dengan penelitian lain yang sudah ada. Teknologi DNA rekombinan terdiri dari pengubahan materi genetik di luar suatu organisme untuk memperoleh karakteristik yang ditingkatkan dan diinginkan pada organisme hidup atau sebagai produknya. Dua analog insulin biosintetik mempunyai durasi kerja yang cukup lama untuk digunakan sebagai insulin basal sekali sehari. Beberapa biosimilar telah dikembangkan untuk insulin manusia seperti yang diproduksi oleh Lilly dan NovoNordisk, namun penggunaannya lebih dibatasi mengingat permasalahan yang dihadapi dalam penggunaan insulin manusia, lihat Dolinar dkk untuk tinjauan terbaru di lapangan. Beberapa perusahaan telah mengembangkan atau sedang mengembangkan persiapan depot yang dapat diberikan satu kali dalam seminggu, bukan sekali sehari. Teknologi DNA rekombinan merupakan perkembangan penting dalam ilmu pengetahuan yang telah membuat hidup manusia lebih mudah. Efek klinis terapi hormon pertumbuhan pada anak-anak paling baik diukur setiap tahun dan dibandingkan dengan prediksi tinggi badan orang dewasa, sedangkan kegagalan menurunkan gula darah dapat langsung terlihat pada terapi insulin atau analog insulin.

References

Riggs AD. Making, Cloning, and the Expressionof Human Insulin Genes in Bacteria: The Path to 12. Humulin. Endocr Rev. 2021 May 25;42(3):374-380.

Isfordink CJ, van Erpecum KJ, van der Valk M, Mauser-Bunschoten EP, Makris M. Viral hepatitis in haemophilia: historical perspective and current management. Br J Haematol. 2021 Oct;195(2):174-185. doi: 10.1111/bjh.17438. Epub 2021 May 6.

Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res Paediatr. 2019;92(1):1-14. doi: 10.1159/000502231. Epub 2019 Sep 12.

Rudge P , Jaunmuktane Z, Adlard P , Bjurstrom N, Caine D, Lowe J, NorsworthyP, HummerichPDruyehR, WadsworthJDF,Brand ner S, Hyare H, Mead S, Collinge J. Brain 2015 Nov;138(Pt 11):3386-99.doi: 10.1093/brain/awv235. Epub 2015 Aug 11.

Mukherjee S, Sayantan Mondal S, Anilrao Deshmukh A, Gopal B, Bagchi B. What Gives an Insulin Hexamer Its Unique Shape and Stability? Role of Ten Confined Water Molecules Phys Chem B 2018 Feb 8;122(5):1631-1637. doi: 10.1021/acs.jpcb.8b00453.Epub 2018 Jan 27.

Boguszewski MCS. Growth hormone deficiency and replacement in children. Rev Endocr Metab Disord. 2021 Mar;22(1):101-108. doi: 10.1007/s11154-020-09604-2. Epub 2020 Oct.

Richmond E, Rogol AD. Treatment of growth hormone deficiency in children, adolescents and at the transitional age. Best Pract Res Clin Endocrinol Metab. 2016 Dec;30(6):749-755. doi: 10.1016/j.beem.2016.11.005. Epub 2016 Nov 4. PMID: 27974188..

Boguszewski MCS, Cardoso-Demartini AA, Boguszewski CL, Chemaitilly W, Higham CE, Johannsson G, Yuen KCJ. Safety of growth hormone (GH) treatment in GH deficient children and adults treated for cancer and non- malignant intracranial tumors-a review of research and clinical practice. Pituitary. 2021 Oct;24(5):810-827. doi: 10.1007/s11102- 021-01173-

Deodati A, Cianfarani S. The Rationale for Growth Hormone Therapy in Children with Short Stature. J Clin Res Pediatr Endocrinol. 2017 Dec 30;9(Suppl 2):23-32.

Thaker V, Haagensen AL, Carter B, Fedorowicz Z, Houston BW. Recombinant growth hormone therapy for cystic fibrosis in children and young adults. Cochrane Database Syst Rev. 2013 Jun 5;6(6):CD008901. doi: 10.1002/14651858.CD008901.pub2.

Dutta D, Mahajan K, Kumar M, Sharma M. Efficacy and safety of long-acting growth hormone in adult growth hormone deficiency: A systematic review and meta-analysis. Diabetes Metab Syndr. 2022 Feb;16(2):102421. doi: 10.1016/j.dsx.2022.102421. Epub 2022 Feb 8. PMID: 35158212

Steiner M, Saenger P. Turner Syndrome: An Update. Adv Pediatr. 2022 Aug;69(1):177- 202.

Rosenberg AGW, Passone CGB, Pellikaan K, Damiani D, van der Lely AJ, Polak M, Bernardo WM, de Graaff LCG. Growth Hormone Treatment for Adults With Prader-Willi Syndrome: A Meta-Analysis. J Clin Endocrinol Metab. 2021 Sep 27;106(10):3068-3091

Fryklund L, Ritzén M, Bertilsson G, Arnlind MH Is the decision on the use of biosimilar growth hormone based on high quality scientific evidence? - a systematic review. Eur J Clin Pharmacol. 2014 May;70(5):509-17. doi: 10.1007/s00228-014-1655-4. Epub 2014 Feb 26.PMID: 24569841 Review.

Matar P, Biosimilarity is not a transitive property: implication for interchangeability, naming and pharmacovigilance. Generics and Biosimilars Initiative Journal (GaBI Journal). 2022;11(1):36-40.

Nicolucci A, Ceriello A, Di Bartolo P, Corcos A, Orsini Federici M. Rapid-Acting Insulin Analogues Versus Regular Human Insulin: A Meta-Analysis of Effects on Glycemic Control in Patients with Diabetes. Diabetes Ther. 2020 Mar;11(3):573-584. doi: 10.1007/s13300- 019-00732-w. Epub 2019 Dec 23. 3

Fullerton B, Siebenhofer A, Jeitler K, Horvath K, Semlitsch T, Berghold A, Plank J, Thomas R Pieber, Ferdinand M GerlachShort-acting insulin analogues versus regular human insulin foradults with type 1 diabetes mellitus Cochrane Database Syst Rev. 2016.

Tibaldi JM Evolution of insulin: from human to analog Am J Med. 2014 Oct;127(10 Suppl):S25-38.

Toledano Y, Hadar E , Hod M, Safety of insulin analogues as compared with human insulin in pregnancy Expert Opin Drug Saf. 2016 Jul;15(7):963-73. doi: 10.1080/14740338.2016.1182153. Epub 2016 May 17. metabolites from somapacitan, a long-acting growth hormone derivative, and pharmacokinetics after single and multiple subcutaneous dosing in rats. Eur J Pharm Sci. 2022 Jan 1;168:106032. doi: 10.1016/j.ejps.2021.106032. Epub 2021 Oct 2. PMID: 34610450

Thygesen P, Andersen HS, Behrens C, Fels JJ, Nørskov-Lauritsen L, Rischel C, Johansen NL. Nonclinical pharmacokinetic and pharmacodynamic characterisation of somapacitan: A reversible non-covalent albumin-binding growth hormone. Growth Horm IGF Res. 2017 Aug;35:8-16. doi:

Miller BS, Blair JC, Rasmussen MH, Maniatis A, Kildemoes RJ, Mori J, Polak M, Bang RB, Böttcher V, Stagi S, Horikawa R. Weekly Somapacitan is Effective and Well Tolerated in Children With GH Deficiency: The Randomized Phase 3 REAL4 Trial. J Clin Endocrinol Metab. 2022 Nov 25;107(12):3378-3388. doi: 10.1210/clinem/dgac513. PMID: 36062966; PMCID: PMC9693810.

Kjaer ASL, Jensen RB, Petersen JH, Linneberg A, Kårhus LL, Henriksen LS, Johannsen TH, Main KM, Hoffman AR, Juul A. Tracking and Cumulative Lifetime Exposure to IGF-I in 6459 Healthy Individuals and in SGA Children Treated With GH. J Clin Endocrinol Metab. 2023 Feb 15;108(3):642-652.

Van der Kaay DCM, Rochtus A, Binder G, Kurth I, Prawitt D, Netchine I, Johannsson G, Hokken- Koelega ACS, Elbracht M, Eggermann T. Comprehensive genetic testing approaches as the basis for personalized management of growth disturbances: current status and perspectives. Endocr Connect. 2022 Oct 10;11(11):e220277.

de Graaff LC, Clark AJ, Tauber M, Ranke MB, Johnston LB, Caliebe J, Molinas C, Amin N, van Duijn C, Wollmann H, Wallaschofski H, Savage MO, Hokken-Koelega AC. Association analysis of ten candidate genes in a large multinational cohort of small for gestational age children and children with idiopathic short stature (NESTEGG study). Horm Res Paediatr. 2013;80(6):466-76. doi: 10.1159/000355409. Epub 2013 Nov

Binder G. Isolated growth hormone deficiency and the GH-1 gene: update 2002. Horm Res.

Dolinar R, Lavernia F, Edelman S. A Guide To Follow-On Biologics And Biosimilars With A Focus On Insulin. Endocr Pract. 2018 Feb;24(2):195-204. doi: 10.4158/EP161728.RA. PMID: 29466056.

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Published

2023-12-31