Perbandingan Polimer pada Tablet Bukal dan Pengaruhnya  pada Penghantaran

Muhammad Fathur Rahman; Rakha Widyastama; Padma Azzahra Ramadhani; Elita rahmah; Zalmiati Zalmi; Nor Latifah

doi:10.29313/jrf.v4i2.5443

Authors

Muhammad Fathur Rahman UNIVERSITAS MUHAMMADIYAH BANJARMASIN
Rakha Widyastama Universitas Muhammadiyah Banjarmasin
Padma Azzahra Ramadhani UNIVERSITAS MUHAMMADIYAH BANJARMASIN
Elita rahmah UNIVERSITAS MUHAMMADIYAH BANJARMASIN
Zalmiati
Nor Latifah UNIVERSITAS MUHAMMADIYAH BANJARMASIN

DOI:

https://doi.org/10.29313/jrf.v4i2.5443

Keywords:

Bukal, Mukoadhesif, Eksipien

Abstract

Abstract.The development of mucoadhesive buccal films has become a focus of pharmaceutical research to improve oral drug delivery. The combination of polymers such as carbopol and HPMC improves film adhesion, while variations in excipients influence physical properties and drug release. The ideal film should be flexible, have a neutral pH, and be able to release the drug in a controlled manner. Although progress has been made, further research is needed for in vivo evaluation and addressing challenges such as interindividual variability. With great potential, mucoadhesive buccal films can be an attractive alternative for oral drug delivery.

Abstrak. Pengembangan film bukal mukoadhesif menjadi fokus penelitian farmasi untuk meningkatkan penghantaran obat oral. Kombinasi polimer seperti karbopol dan HPMC meningkatkan adhesi film, sedangkan variasi eksipien memengaruhi sifat fisik dan pelepasan obat. Film yang ideal harus fleksibel, memiliki pH netral, dan dapat melepaskan obat secara terkontrol. Meskipun kemajuan telah dicapai, penelitian lebih lanjut diperlukan untuk evaluasi in vivo dan mengatasi tantangan seperti variabilitas antar individu. Dengan potensi yang besar, film bukal mukoadhesif dapat menjadi alternatif menarik untuk penghantaran obat oral.

References

Ansari, M., Sadarani, B., & Majumdar, A. (2017). Optimization and evaluation of mucoadhesive buccal film loaded with resveratrol. Journal of Drug Delivery Science & Technology, 1–22.

Bhargava, M., & Joshi, V. (2016). Novel buccal drug delivery systems. Research Journal of Pharmacy and Technology, 9, 102–108.

Chandrakar, K.K., Grabowski, W.W., Morrison, H., & Bryan, G.H. (2021). Impact of entrainment-mixing and turbulent fluctuations on droplet size distributions in a cumulus cloud: An investigation using Lagrangian microphysics with a sub-grid-scale model. Journal of the Atmospheric Sciences, 78(9), 2983–3005. https://doi.org/10.1175/JAS-D-20-0281.1

Desai, P., et al. (2019). Advantages of buccal drug delivery. Journal of Applied Pharmaceutical Science, 5, 15–21.

Gupta, R., et al. (2022). Advances in buccal adhesive drug delivery. Journal of Pharmaceutical Innovations, 24, 88–94.

Hussain, A., et al. (2019). Solidified SNEDDS for the oral delivery of rifampicin: Evaluation, proof of concept, in vivo kinetics, and in silico GastroPlusTM simulation. International Journal of Pharmaceutics, 566, 203–217. https://doi.org/10.1016/j.ijpharm.2019.05.061

Inayah, S., Lizma, F., Novita, E., & Jaka, F. (2018). Formulasi dan evaluasi sediaan patch bukal mukoadhesif celecoxibe. Proceeding of the 8th Mulawarman Pharmaceutical Conferences. ISSN: 2614-4778.

Jain, A., et al. (2021). Oral mucosal delivery of drugs. Journal of Pharmaceutical Sciences, 19, 41–48.

Kazi, M., et al. (2020). Enhancing oral bioavailability of apigenin using a bioactive selfnanoemulsifying drug delivery system (Bio-SNEDDS): In vitro, in vivo and stability evaluations. Pharmaceutics, 12(8), 1–22. https://doi.org/10.3390/pharmaceutics12080749

Kumar, S., & Mandal, U. (2018). Mucoadhesive drug delivery. Journal of Drug Delivery and Therapeutics, 8, 152–158.

Mehta, P., et al. (2015). Challenges in buccal drug formulations. Current Pharmaceutical Design, 21, 254–260.

Padsala, K., Desai, K., & Swamy, S.M.V. (2014). Formulasi, evaluasi dan optimalisasi tablet bukal mukoadhesif simvastatin. Pharma Sci Monitor, 5(2), 55–79.

Patel, R., et al. (2020). Buccal drug delivery systems. International Journal of Drug Delivery, 12, 45–52.

Prajapati, V., et al. (2017). Bioavailability enhancement of drugs via buccal route. Pharmaceutical Research, 34, 85–93.

Puspitary, K. (2019). Optimai formula tablet bukoadhesive piroksikam dengan polimer kitosin, karbopol 940P, serta penghancur PEG 6000. Jurnal Kesehatan Tujuh Belas (Jurkes TB), Vol.1, No.1 2019, 39.

Puspita, S.D., Pramulani, M., & Nining. (2022). Review: Komposit polimer pektin dalam sistem penghantar obat. Majalah Farmasetika, 7(1), 1–7.

Russo, E., Selmin, F., Baldassari, S., & Parodi, B. (2016). Fokus pada polimer mukoadhesif dan aplikasinya dalam bentuk sediaan bukal. Journal of Drug Delivery Science and Technology, 32(B), 113–125.

Sharma, R., & Vora, Z. (2018). Mucoadhesive buccal tablets. Journal of Drug Delivery, 10, 38–44.

Shtenberg, Y., Goldfeder, M., Prinz, H., Shainsky, J., Ghantous, Y., Abu El-Naaj, I., et al. (2018). Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery. International Journal of Biological Macromolecules, 111, 62–69.

Singh, S., & Kumar, A. (2019). Formulation aspects of buccal tablets. International Journal of Pharmaceutical Sciences, 11, 67–74.

Verma, R., et al. (2021). Improved pharmacodynamic potential of rosuvastatin by self-nanoemulsifying drug delivery system: An in vitro and in vivo evaluation. International Journal of Nanomedicine, 16, 905–924. https://doi.org/10.2147/IJN.S287665

Yang, J., Huang, Y., Gao, C., Liu, M., & Zhang, X. (2014). Fabrication and evaluation of the novel reduction-controlled drug release. Colloids and Surfaces B: Biointerfaces, 115, 368–376.