Potensi Tanaman Jeruk Nipis (Citrus aurantifolia) Sebagai Antikanker
DOI:
https://doi.org/10.29313/jrf.v3i2.3123Keywords:
Kanker, jeruk nipis, Citrus aurantufoliaAbstract
Abstract. Lime (Citrus aurantifolia) is one of the plants known to have anticancer effects. The use of lime as an anticancer has been scientifically researched, but has not been presented holistically. Therefore, this research was conducted in a Systematic Literature Review (SLR) so that it can be used as a reference in the development of new anticancer drugs. This literature research aims to recognize the potential and mechanism of lime plants in inhibiting cancer cell proliferation and determine the IC50 value that can inhibit cancer cell poliferation where data retrieval is carried out on Google Scholar, PubMed and Science Direct portals so that seven articles are obtained that meet the criteria of this study. The results of the analysis show that lime peel plant (Citrus aurantifolia) has the ability as an anticancer through mechanism such as induction of apoptosis and has potential in the IC50 values range of 2,18 µg/mL – 320 µg/mL where in that range lime plants are said to have very strong, moderately active to low as anticancer. The best anticancer activity of lime plants is found in lime peel extract againts colorectal cancer cells lim 1863 with IC50 values in the range of 2,18 µg/mL.
Abstrak. Jeruk nipis (Citrus aurantifolia) ialah salah satu tumbuhan yang dikenal mempunyai efek sebagai antikanker. Pemakaian jeruk nipis sebagai antikanker sudah banyak dilakukan riset secara ilmiah, tetapi belum tersajikan secara holistik. Oleh sebab itu, penelitian ini dilakukan secara Sistematic Literature Review (SLR) sehingga bisa dijadikan rujukan dalam pengembangan obat baru antikanker. Riset literatur ini bertujuan untuk mengenali potensi dan mekanisme tanaman jeruk nipis dalam menghambat poliferasi sel kanker serta mengetahui nilai IC50 yang dapat menghambat poliferasi sel kanker dimana pengambilan data dilakukan pada portal Google Scholar, PubMed serta Science Direct sehingga diperoleh sebanyak tujuh artikel yang memenuhi kriteria penelitian ini. Hasil analisis menunjukkan bahwa tanaman jeruk nipis (Citrus aurantifolia) mempunyai kemampuan sebagai antikanker melalui mekanisme seperti induksi apoptosis serta memiliki potensi pada rentang nilai IC50 sebesar 2,18 µg/mL – 320 µg/mL dimana pada rentang tersebut tanaman jeruk nipis dikatakan memiliki aktivitas yang sangat kuat, moderat aktif hingga rendah sebagai antikanker. Aktivitas antikanker tanaman jeruk nipis yang paling baik terdapat pada ekstrak kulit jeruk nipis terhadap sel kanker kolorektal lim 1863 dengan nilai IC50 pada rentang 2,18 µg/mL.
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