Studi Literatur Efek Farmakologi Rimpang Temu Kunyit Putih (Curcuma zedoaria)
DOI:
https://doi.org/10.29313/jrf.v3i1.2692Keywords:
Curcuma zedoaria, Mechanism of Action, Effect of PharmacologyAbstract
Abstract. Lime (Citrus aurantifolia) is one of the plants known to have anticancer effects. The use of lime as an anticancer has been scientifically researched, but has not been presented holistically. Therefore, this research was conducted in a Systematic Literature Review (SLR) so that it can be used as a reference in the development of new anticancer drugs. This literature research aims to recognize the potential and mechanism of lime plants in inhibiting cancer cell proliferation and determine the IC50 value that can inhibit cancer cell poliferation where data retrieval is carried out on Google Scholar, PubMed and Science Direct portals so that seven articles are obtained that meet the criteria of this study. The results of the analysis show that lime peel plant (Citrus aurantifolia) has the ability as an anticancer through mechanism such as induction of apoptosis and has potential in the IC50 values range of 2,18 µg/mL – 320 µg/mL where in that range lime plants are said to have very strong, moderately active to low as anticancer. The best anticancer activity of lime plants is found in lime peel extract againts colorectal cancer cells lim 1863 with IC50 values in the range of 2,18 µg/mL.
Abstrak. Jeruk nipis (Citrus aurantifolia) ialah salah satu tumbuhan yang dikenal mempunyai efek sebagai antikanker. Pemakaian jeruk nipis sebagai antikanker sudah banyak dilakukan riset secara ilmiah, tetapi belum tersajikan secara holistik. Oleh sebab itu, penelitian ini dilakukan secara Sistematic Literature Review (SLR) sehingga bisa dijadikan rujukan dalam pengembangan obat baru antikanker. Riset literatur ini bertujuan untuk mengenali potensi dan mekanisme tanaman jeruk nipis dalam menghambat poliferasi sel kanker serta mengetahui nilai IC50 yang dapat menghambat poliferasi sel kanker dimana pengambilan data dilakukan pada portal Google Scholar, PubMed serta Science Direct sehingga diperoleh sebanyak tujuh artikel yang memenuhi kriteria penelitian ini. Hasil analisis menunjukkan bahwa tanaman jeruk nipis (Citrus aurantifolia) mempunyai kemampuan sebagai antikanker melalui mekanisme seperti induksi apoptosis serta memiliki potensi pada rentang nilai IC50 sebesar 2,18 µg/mL – 320 µg/mL dimana pada rentang tersebut tanaman jeruk nipis dikatakan memiliki aktivitas yang sangat kuat, moderat aktif hingga rendah sebagai antikanker. Aktivitas antikanker tanaman jeruk nipis yang paling baik terdapat pada ekstrak kulit jeruk nipis terhadap sel kanker kolorektal lim 1863 dengan nilai IC50 pada rentang 2,18 µg/mL.
References
Chen, L., Lu, X., El-Seedi, H., & Teng, H. (2019). Recent advances in the development of sesquiterpenoids in the treatment of type 2 diabetes. Trends in Food Science and Technology, 88(December 2018), 46–56. https://doi.org/10.1016/j.tifs.2019.02.003
Handajani, J., & Narissi, D. H. (2015). The effects of Curcuma zedoaria oil on high blood sugar level and gingivitis. Dental Journal (Majalah Kedokteran Gigi), 48(2), 69. https://doi.org/10.20473/j.djmkg.v48.i2.p69-73
Holley, P. (1988). Stabbed in the back. Nursing Standard, 2(13), 36–36. https://doi.org/10.7748/ns.2.13.36.s79
Iguchi, M., Hiroi, M., Kanegae, H., & Ohmori, Y. (2018). Costimulation of Murine Osteoblasts with Interferon- γ and Tumor Necrosis Factor- α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria. Mediators of Inflammation, 2018. https://doi.org/10.1155/2018/3979606
Jung, E. B., Trinh, T. A., Lee, T. K., Yamabe, N., Kang, K. S., Song, J. H., Choi, S., Lee, S., Jang, T. S., Kim, K. H., & Hwang, G. S. (2018). Curcuzedoalide contributes to the cytotoxicity of Curcuma zedoaria rhizomes against human gastric cancer AGS cells through induction of apoptosis. Journal of Ethnopharmacology, 213, 48–55. https://doi.org/10.1016/j.jep.2017.10.025
Lee, T. K., Lee, D., Lee, S. R., Ko, Y. J., Sung Kang, K., Chung, S. J., & Kim, K. H. (2019). Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells. Bioorganic Chemistry, 87(February), 117–122. https://doi.org/10.1016/j.bioorg.2019.03.015
Lee, T. K., Trinh, T. A., Lee, S. R., Kim, S., So, H. M., Moon, E., Hwang, G. S., Kang, K. S., Kim, J. H., Yamabe, N., & Kim, K. H. (2019). Bioactivity-based analysis and chemical characterization of anti-inflammatory compounds from Curcuma zedoaria rhizomes using LPS-stimulated RAW264.7 cells. In Bioorganic Chemistry (Vol. 82). https://doi.org/10.1016/j.bioorg.2018.09.027
Li, J., Bian, W. H., Wan, J., Zhou, J., Lin, Y., Wang, J. R., Wang, Z. X., Shen, Q., & Wang, K. M. (2014). Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Asian Pacific Journal of Cancer Prevention, 15(22), 9997–10001. https://doi.org/10.7314/APJCP.2014.15.22.9997
Maulana, M. A. (2023). Potensi Antiinflamasi Ekstrak Etanol Biji Kurma Ajwa Terhadap Tikus Wistar Jantan. Jurnal Riset Farmasi, Vol 3 no 1. https://doi.org/https://doi.org/10.29313/jrf.v3i1.1795
Patala, R., Levita, J., & Milanda, T. (2018). Aktivitas Penghambatan in Vitro Dan Penambatan Molekular Senyawa Flavonoid Pada Inducible Nitric Oxide Synthase : Review. Farmaka, 16(3), 22–30.
Shehna, S., Sreelekshmi, S., Remani, P. R., Padmaja, G., & Lakshmi, S. (2022). Anti-cancer, anti-bacterial and anti-oxidant properties of an active fraction isolated from Curcuma zedoaria rhizomes. Phytomedicine Plus, 2(1), 100195. https://doi.org/10.1016/j.phyplu.2021.100195
Tariq, S., Imran, M., Mushtaq, Z., & Asghar, N. (2016). Phytopreventive antihypercholesterolmic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe.) herbal tea. Lipids in Health and Disease, 15(1), 1–10. https://doi.org/10.1186/s12944-016-0210-y
Tsuge, K., Inazumi, T., Shimamoto, A., & Sugimoto, Y. (2019). Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases. International Immunology, 31(9), 597–606. https://doi.org/10.1093/intimm/dxz021
Wardhani, F. M., Chiuman, L., Ginting, C. N., Ginting, S. F., & Nasution, A. N. (2019). Efek Ekstrak Kunyit Putih (Curcuma Zedoaria) Sebagai Nefroprotektor Pada Tikus Putih Jantan Galur Wistar yang Diinduksi Tembaga. Journal Of The Indonesian Medical Association, 69(8), 260.
Zhang, R., Pan, T., Xiang, Y., Zhang, M., Xie, H., Liang, Z., Chen, B., Xu, C., Wang, J., Huang, X., Zhu, Q., Zhao, Z., Gao, Q., Wen, C., Liu, W., Ma, W., Feng, J., Sun, X., Duan, T., … Sui, X. (2022). Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. Bioactive Materials, 13(September 2021), 23–36. https://doi.org/10.1016/j.bioactmat.2021.11.013